BioForm Medical, Inc. aleading medical device company that develops and commercializes injectableimplant products for soft tissue augmentation announced the results of arigorous clinical study confirming the long-term efficacy of Radiesse forthe treatment of Vocal Fold Insufficiency. This common voice-alteringcondition is a serious form of voice loss in which one or both vocal folds(and cords) lack the physical capacity to vibrate properly. Radiessetreatment has demonstrated success in improving the voice of patients for12 months without surgery.

Lead investigator and voice specialist Clark A. Rosen, M.D., presentednew study data showing that 73% of study patients reported their voice wasgreatly or significantly improved 12 months after Radiesse treatment. Thescientific findings were reported during the annual Combined OtolaryngologySpring Meetings (COSM) in Chicago on May 19-22, 2006.

"The data collected in this study is very beneficial for managingpatients with vocal fold insufficiency because we can provide along-lasting treatment option to patients who previously were resigned tolive with their condition or have an 'open' neck surgery," said Dr. Rosen,director of the University of Pittsburgh Voice Center. "So many patientssuffer with voice problems that limit their quality of life because theydon't know that there are safe, simple treatment options which often can bedone in the office."

This investigation is the largest multi-center, open-label, prospectiveclinical study of its kind in the field of voice disorders. More than 100patients were enrolled at 11 clinical centers in the United States andEurope. Most patients received one treatment with Radiesse, which wasinjected into the affected vocal fold(s) to modify the larynx and cause thevocal folds to meet at midline. Voice-related outcome measures werecollected for pre- injection and at one, three, six and 12 monthspost-injection. Dr. Rosen noted that "these results are significant becausethey demonstrate Radiesse to be a safe, effective vocal fold augmentationmaterial that can be injected in the office or operating room withexcellent, long-term voice results."

Radiesse is the first non-surgical vocal fold treatment that has proven12 months of effectiveness in a rigorous clinical study of vocal foldinsufficiency.

Patients received treatment with Radiesse for two types of voicedisorders: paralysis of the vocal folds in which one of the vocal cordsdoesn't move to meet the middle opening between the two vocal folds; andglottal incompetence in which the two vocal cords move but are thin andweak and don't meet together to close the middle opening completely(usually due to muscle damage or muscle loss associated with aging).

-- The mean voice handicap index scores, a standard assessment tool used to measure vocal recovery, were improved at the 12-month follow-up time point.

-- Objective voice testing of maximum phonation test, a measure of how long a person can say "ah" on one breath showed a statistically significant improvement comparing pre-treatment and the 12-month follow-up time points.

Manufactured and distributed in the U.S. by BioForm Medical, Inc.,Radiesse is an injectable filler used in various cosmetic, reconstructiveand ENT applications to augment and contour folds, depressions and vocalfold defects of the facial area. Composed of tiny calcium hydroxylapatite(CaHA) particles suspended in a water-based gel carrier, Radiesse has beenproven safe and biocompatible in numerous soft tissue applications. Amongthe product's many advantages, Radiesse treatment allows steady growth ofcollagen matrix, produces virtually instant results, and lasts one to threeyears. For more information, please visit http://www.radiesse.com .

Headquartered in San Mateo, CA, BioForm Medical, Inc., is aprivately-held medical device company developing and commercializinginjectable implant products for soft and hard tissue augmentation andtopical preparations for dermatological conditions. The Company isdedicated to improving patients' lives by providing high quality,innovative, safe and effective medical products for use in the plasticsurgery, dermatology, urology, and ENT markets.

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