July 5, 2006 - The quest for a more youthful appearance usually starts with the face, but an increasing number of women are now focusing on their hands.

A manicure, even a massage, can help give hands a quick pick me up. But the dark spots, wrinkles and those unsightly veins are still there. A woman's hands can tell a lot about her age.

The skin on the back of the hands is more delicate and as we age fat that normally pads this area begins breaking down. The result: you see more of the bones, muscles and veins.

Brink wants her hands to match her face and plastic surgeon Michael Epstein has some solutions. First, sclerotherapy to eliminate the veins. It's the same procedure used to eliminate spider veins in the legs.

"You can easily, very easily inject the back of the hands and cause those veins to thrombosis which is basically to clot off. Once they clot off um they just shrivel up and fade away," said Dr. Michael Epstein, plastic surgeon.

Then, in a more involved process called fat grafting, Jean's hands are plumped back up with small amounts of fat harvested from her leg, which are then redeposited in her hands through a syringe.

There are more conservative approaches to rejuvenating hands and keeping them youthful Dermatologist Omeed Memar says, for starters, make it a habit to slather sunscreen on your hands.

If you're looking to diminish fine lines, there are topical vitamin-A-based retinoid creams, such as Retin-A, which promote skin cell turnover and collagen stimulation.

You can expect to pay several thousand dollars for fat grafting and $300 to $600 for sclerotherapy. Other procedures, such as the laser treatments and microdermabrasion, will also run several hundred dollars.

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